On December 11, 2015, Brandon faced Paul Cheng in the main event at ONE Championship: Spirit of Champions. He won the fight via knockout just 26 seconds into the first round to win the very first ONE Heavyweight Championship!
For the next five years, Brandon successfully defended his championship and even battled Aung La Nsang for the ONE Light Heavyweight Championship.
At the end of 2022, Brandon Vera fought courageously in front of a capacity crowd in Manila, Philippines, breaking his hand in his final fight then immediately announcing his retirement in front of his fellow Filipinos.